Tablet Formulation Guide

Select all four API Criteria to find the best Process, Excipients, Comments and JRS Formulation Handbook Reference

API Criteria
 
 
Process Challenges: Case0 Recommended Method:  
     
     
Excipient Binder:            
  Filler/Binder:        
          
           
           
         
  Disintegrant:       
          
          
           
  Lubricant:        
Comments          
JRS Formulation
Handbook Reference
Click on link to visit page		        
         
         
Process Challenges: Powder Flow Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Excipient Binder: VIVAPHARM® PVP K 30 or VIVAPHARM® PVP K 30
  Filler/Binder: One of the following: or PROSOLV® EASYtab SP
    VIVAPUR MCC® (Any DC grade)    
    EMOCEL® 90 MCC    
    PROSOLV® 90 SMCC    
    EMDEX® Dextrates    
  Disintegrant: One of the following: and VIVASOL®
    VIVASTAR® SSG    
    EXPLOTAB® SSG    
    VIVAPHARM® PVPP    
  Lubricant: PRUV® SFF or Mg stearate    
Comments Alternatively use a blend of PROSOLV® SMCC 50 LD (70%) and EMCOMPRESS® Anhydrous (30%) in the ribbon, use binder intra- and extragranularly
Alternatively use a blend of PROSOLV® SMCC 50 LD (70%) and EMCOMPRESS® Anhydrous (30%) in the ribbon, use binder intra- and extragranularly
JRS Formulation
Handbook Reference
Click on link to visit page		 Acetylsalicylic Acid 4282-001 Link line 1B Link line 1C  
Link line 2A Link line 2B Link line 2C    
Link line 3A Link line 3B Link line 3C    
Process Challenges: No particular challenge Recommended Method: Direct Compression
     
     
Excipient Binder: no binder
 
  Filler/Binder: One of the following:
 
    VIVAPUR MCC® (Any DC grade)
 
    EMOCEL® 90 MCC
 
    PROSOLV® 90 SMCC
 
    EMDEX® Dextrates
or   PROSOLV® EASYtab SP
  Disintegrant: VIVASOL® CCS
 
     
 
     
 
     
 
  Lubricant: PRUV® SFF  or  Mg stearate
 
Comments Select filler/binder grade according to API's particle size distribution
If using PROSOLV® EASYtab SP, add more disintegrant and lubricant, if need should be  
JRS Formulation
Handbook Reference
Click on link to visit page		 Ranitidine HCl 4282-020      
         
         
Process Challenges: Powder Flow Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Excipient Binder: VIVAPHARM® PVP K 30 or VIVAPHARM® PVP K 30
  Filler/Binder: One of the following: or PROSOLV® EASYtab SP
    VIVAPUR MCC® (Any DC grade)    
    EMOCEL® 90 MCC    
    PROSOLV® 90 SMCC    
    EMDEX® Dextrates    
  Disintegrant: One of the following: and VIVASOL®
    VIVASTAR® SSG    
    EXPLOTAB® SSG    
    VIVAPHARM® PVPP    
  Lubricant: PRUV® SFF or Mg stearate
Comments Alternatively use a blend of PROSOLV® SMCC 50 LD (70%) and EMCOMPRESS® Anhydrous (30%) in the ribbon, use binder intra- and extragranularly  
JRS Formulation
Handbook Reference
Click on link to visit page		 Acetylsalicylic Acid 4282-001 Link line 1B Link line 1C  
Link line 2A Link line 2B Link line 2C    
Link line 3A Link line 3B Link line 3C    
Process Challenges: Case3 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case4 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case5 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case6 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case7 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case8 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case9 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case10 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case11 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case12 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case13 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case14 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case15 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case16 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case17 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case18 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case30 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution   
Process Challenges: Case99 Recommended Method: Wet granulation (fluid bed)
 Compaction   
 Dissolution